GW4 NanoMedicine Workshop

GW4 NanoMedicine Consortium

GW4, NANOMEDICINE WORKSHOP

GW4 NanoMedicine: Key Challenges and Future Directions

 

GW4 NanoMedicine Workshop

Key Challenges and Future Directions​

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GW4 NanoMedicine Workshop
GW4 NanoMedicine Workshop

GW4 NanoMedicine Workshop

GW4 Nanomedicine workshop review – by Charlie Jeynes (University of Exeter)

 

 

The meeting opened with Dr. Charlie Jeynes introducing the aims of the day and a brief overview of the multidisciplinary nature of ‘nanomedicine’ and accomplishments of the field thus far.

 

One key aim was to initiate a new GW4 network that was able to identify the most pressing issues within nanomedicine research. To this end, delegates were invited to write key words on post-it notes that encapsulated topics that they wanted to discuss during the day, such as nanoparticles & the immune system. Indeed, we used these notes at the end of the workshop to form groups.

About Us

We are a group of multidisciplinary researchers:

 

Our Aims

Our longer term aim is to co-ordinate a critical mass of ’NanoMedicine’ researchers across GW4 and beyond, so that we concentrate on the most important questions that will enable this important technology to enter into clinical practice

9:30-10:20 Registration & coffee

 

10:20-10:30 Introduction to GW4 NanoMedicine team and vision (GW4 team)

 

Session 1: Chair: Karen Edler (University of Bath)

 

10:30 - 11:00 Prof Arwyn Jones (University of Cardiff)

Endocytosis for Drug Delivery: Breaking the Lock or Using the Key to get Nanoparticles and Receptors into Cells?

 

11:00 - 11:30 One minute flash presentations from all delegates - Part 1

 

11:30 - 12:00 Coffee (pin topics to board)

 

Session 2: Chair: Ash Toye (University of Bristol)

 

12:00 - 12:30 Dr Sabine Hauert (University of Bristol)

AI-driven engineering of cooperative nanomedicine

 

12:30 - 13:00 Prof Sofia Pascu  (University of Bath)

New radio-nanomedicines: encapsulation of radiometal ions and luminescent nanocrystals in biocompatible nanotubes and layered nanomaterials

 

13:00 - 14:00 Lunch & posters

 

Session 2: Chair: Mark Young (University of Cardiff)

 

14:00 - 14:30 Prof Aled Clayton (University of Cardiff)

Extracellular (nano)vesicles – natures vectors

 

14:30 - 15:00 Dr Helen Townley  (University of Oxford, Co-founder Xerion Healthcare)

Nanoparticles for cancer therapy; translation from the lab to the clinic

 

15:00 - 15:15 Ali Mohammed (University of Bath)

1. Programmable Microelectromechanical Systems (MEMS) for Lab on Chip devices, and 2. Micro-Energy Harvesting for Implantable Electronics 

 

 15:15 - 15:30 Marjolein Meinders (University of Bristol)

“Engineered Red blood cells as therapeutics“

 

15:30 - 16:00 Coffee

 

Session 3: Chairs: Riccardo Bonsignore & Andreia De Almeida (University of Cardiff)

 

16:00 - 16:30 Dr. Bertram Daum (ERC Fellow, University of Exeter)

Biohybrid microrobots inspired by extremophiles

 

16:30 17:00 Prof. Julian Moger (University of Exeter)

Driving the development of nanomedicines using CARS

 

17:00 - 17:10 Short Break

 

Session 4: Chairs: Charlie Jeynes & David Richards (University of Exeter)

 

1710 - 17:35 Break out session into small groups to discuss key challenges and possible solutions important to your research (details of sorting to be decided)

 

17:35 - 17:50 Feedback from each group & discussion

 

17:50 - 18:00 Summary, ideas for collaboration & introduction to the GW4 NanoMedicine website

 

18:00 - 19:00 Drinks and posters (at Reed Hall)

 

19:30 - 21:30 Dinner served at Holland Hall (ten minutes walk from Reed Hall)

Collection of keys for those wishing an overnight stay

ABOUT

GW4 NanoMedicine Workshop
GW4 NanoMedicine Workshop

9.30-10.20 Registration & coffee

 

10.20-10.30 Introduction to GW4 NanoMedicine team and vision (GW4 team)

 

Session 1: Chair: Karen Edler (University of Bath)

 

10:30 - 11:00 Prof Arwyn Jones (University of Cardiff)

Endocytosis for Drug Delivery: Breaking the Lock or Using the Key to get Nanoparticles and Receptors into Cells?

 

11:00 - 11:30 One minute flash presentations from all delegates - Part 1

 

11:30 - 12:00 Coffee (pin topics to board)

 

Session 2: Chair: Ash Toye (University of Bristol)

 

12:00 - 12:30 Dr Sabine Hauert (University of Bristol)

AI-driven engineering of cooperative nanomedicine

 

12:30 - 13:00 Prof Sofia Pascu  (University of Bath)

New radio-nanomedicines: encapsulation of radiometal ions and luminescent nanocrystals in biocompatible nanotubes and layered nanomaterials

 

13:00 - 14:00 Lunch & posters

 

Session 2: Chair: Mark Young (University of Cardiff)

 

14:00 - 14:30 Prof Aled Clayton (University of Cardiff)

Extracellular (nano)vesicles – natures vectors

 

14:30 - 15:00 Dr Helen Townley  (University of Oxford, Co-founder Xerion Healthcare)

Nanoparticles for cancer therapy; translation from the lab to the clinic

 

15:00 - 15:15 Ali Mohammed (University of Bath)

1. Programmable Microelectromechanical Systems (MEMS) for Lab on Chip devices, and 2. Micro-Energy Harvesting for Implantable Electronics 

 

15:15 - 15:30 Marjolein Meinders (University of Bristol)

“Engineered Red blood cells as therapeutics“

 

15:00 - 16:00 Coffee

 

Session 3: Chairs: Riccardo Bonsignore & Andreia De Almeida (University of Cardiff)

 

16:00 - 16:30 Dr. Bertram Daum (ERC Fellow, University of Exeter)

Biohybrid microrobots inspired by extremophiles

 

16:30 17:00 Prof. Julian Moger (University of Exeter)

Driving the development of nanomedicines using CARS

 

17:00 - 17:10 Short Break

 

Session 4: Chairs: Charlie Jeynes & David Richards (University of Exeter)

 

17:10 - 17:35 Break out session into small groups to discuss key challenges and possible solutions important to your research (details of sorting to be decided)

 

17:35 - 17:50 Feedback from each group & discussion

 

17:50 - 18:00 Summary, ideas for collaboration & introduction to the GW4 NanoMedicine website

 

18:00 - 19:00 Drinks and posters (at Reed Hall)

 

19:30 - 21:30 Dinner served at Holland Hall (ten minutes walk from Reed Hall)

Collection of keys for those wishing an overnight stay

GW4 NANOMEDICINE WORKSHOP
NanoMedicine Workshop
GW4 NanoMedicine Workshop
GW4 NanoMedicine Workshop
GW4 NANOMEDICINE WORKSHOP

We have received funding for a GW4 ‘initiator' grant for ‘ Nanomedicine: 

Current Challenges & Future Directions

Charlie Jeynes (Exeter)

David Richards (Exeter)

Ash Toye (Bristol)

Karen Edler (Bath)

 

GW4 NanoMedicine Workshop

The Workshop

Prof. Arwyn Jones (University for Cardiff), kicked off the talks with a presentation entitled “Endocytosis for drug delivery: breaking the lock or using the key to get nanoparticles and reception into cells”, followed by 25 ‘one-minute flash talks’ by many of the attending delegates. It was clear that there was a diverse range of researchers at the workshop, from cell biologists to mathematical modellers.

 

Throughout the course of the day, we had many fascinating talks including from Dr. Sabine Hauert (University of Bristol) who gave a movie-dotted presentation on using modelling and AI robotic approaches applied to nanomedicine. Dr Helen Townley (University of Oxford) gave a very insightful view into developing nanomedicine research into a spin-out company – and the many pitfalls that can accompany the process! Details of all the speakers can be found on the GW4 nanomedicine website. We also had over 20 posters which were presented throughout the day and stimulated many discussions on new collaborations.

 

In the last session we organised into working groups themed from the notes posted throughout the day. The focus of these groups was to develop a pitch for ‘seedcorn’ ideas that a GW4 Accelerator Award could fund. Examples of these themes included ‘Imaging in Nanomedicine’, ‘Automation in Nanomedicine’ and ‘The immune system and Nanomedicine’. Pitches included using ‘seedcorn’ funds for specialist cryo-EM technician time to further nanomedicine research. Some of these ideas will form the basis of an Accelerator grant – that all delegates will be able to contribute towards.

 

We concluded the day with a much-needed drinks reception followed by a three-course evening meal at Holland Hall. It was a beautiful summers day and many conversations extending long into the night at Holland Hall’s bar with its fabulous views over Exeter. Overall the workshop was a great success with many delegates commenting on how keen they were to continue the series and work on forming an Accelerator community.

The GW4 Nanomedicine workshop was held in Reed Hall, University of Exeter, 16th July 2019 sponsored by the GW ‘initiator’ award. The meeting was attended by over 50 delegates from the GW4 Universities and beyond, including Universities of Oxford and the University of Cologne.

Advertising for the event!!

Advertising for the event!!​

Charlie Jeynes (UoE) kicking off the event

Charlie Jeynes (UoE) kicking off the event​

Interesting discussion over lunch

Interesting discussion over lunch​

Sabine Hauert (UoB) presenting on AI in nanomedicine

Sabine Hauert (UoB) presenting on AI in nanomedicine​

Drinks reception!

Drinks reception!​

Examples of ‘seedcorn’ ideas

Examples of ‘seedcorn’ ideas​

WHAT HAPPENED ON THE DAY

What happened on the day
GW4 NANOMEDICINE WORKSHOP

This short animation introduces ’nanoparticles’

Nanoparticles can convert electromagnetic energy into heat, for instance from near-infra-red light, making them attractive candidates for ’thermal’ therapies. This animation shows how this could work and illustrates some future applications of nanoparticles in medicine.